Parkinson disease (PD), a devastating disease occurs in one out of 100 people over age 65.
It is a slowly progressive disease of the nervous system that causes progressive destruction of the cells (neurons) brain in an area of the brain called the substance negra.La death usually occurs as a result of secondary complications such as infection.
One of the mechanisms known to destroy nerve cells is the damage caused by free radicals or reactive species oxygen - destructive molecules produced by the oxidation of the neurotransmitter dopamine.
The role of dopamine
SUBSTANTIA cells use dopamine - a chemical Messenger between brain and nerve cells - to communicate with cells in other region of the brain called the striated.
When nigral cells are lost, dopamine fall nigral, resulting in a decrease of striatal dopamine levels.
Typical symptoms of PD - deficiencies of motor function characterized by muscle rigidity, jerky, rhythmic movements of sleep - tremors are the result of low levels of striatal dopamine.
Most of dopaminergic, which are used to treat the PD, drugs are aimed to temporarily replacement or imitating dopamine.Improve some symptoms, but does not restore the normal function of the brain, or stop the destruction of brain cells.
Dopaminergic drugs are generally effective in the first place to reduce many of the symptoms of PD, but eventually lose its effect.
Also cause serious side effects because overstimulate the nerve cells elsewhere in the body and cause confusion, hallucinations, nausea and fluctuations in the movement of limbs.
The role of antioxidants
When dopaminergic neurons are lost in the course of Parkinson's disease, increases the metabolism of dopamine - which in turn increases the formation of highly neurotoxic hydroxyl radicals.
Radical scavenging free more important in the cells of the black substance is powerful antioxidant brain, glutathione levels of glutathione in PD patients are low.
And as it ages, lowers levels of glutathione in substantia dopaminergic neurons.This seems to accelerate cell death and advance the progression of the PD.
At least 80 percent of substantia cells are lost before the symptoms of Parkinson's disease become aparente.Por that, it is essential to protect or maintain these cells under oxidative stress.
How to help the glutathione in Parkinson's disease?
Several factors explain why the glutathione is so beneficial in Parkinson's disease.
1. The glutathione increases the sensitivity of the brain to dopamina.Por what although glutathione does not raise the levels of dopamine, allows dopamine in the brain to be more effective.
2 Powerful antioxidant activity of glutathione protects brain damage from free radicals.
3. An even more intriguing glutathione benefit lies in its ability of powerful detoxification.
Its a well known fact that most Parkinson's patients are deficient in its ability to detoxify the chemicals they are exposed.
The unfortunate few hosting a hereditary defect in their process of detoxification risk a much greater brain damaging effects of a wide range of toxins.
Glutathione is one of the most important of the h?gado.La detoxification system components glutathione therapy is one of the most effective techniques to improve liver and brain detoxification.
Glutathione treatment significantly improved including difficulties with stiffness Parkinson's symptoms, walking, movement, coordination, and the discurso.Se has noted a marked reduction of tremor, as well as a decrease in depression.
Glutathione and N-n - acetyl-L-cysteine (a precursor to glutathione) have proved to be very effective in protecting nerves in substantia destroyed by oxidative stress.
Therapy of glutathione in Parkinson's disease
The practical problem in increasing levels of glutathione is taking glutathione itself as a supplement increases not cellular, glutathione levels since glutathione decomposes into the digestive tract soon reaches the cells.
However, glutathione intravenous therapy glutathione precursors and bearing are effective in increasing intracellular levels of glutathione.
Intravenous therapy of glutathione:
Glutathione intravenous injections have shown amazing fast results.
Dr. David Perlmutter, a pioneer in this therapy, has developed a protocol used in Perlmutter Health Centre for administering intravenous glutathione for Parkinson's patients.
In the wake of even a single dose of intravenous glutathione - often in just 15 minutes - the ability to walk, turn around and move his arms is almost completely restored.
Glutathione precursor:
Dietary antioxidants and supplements that increase cellular glutathione, such as NAC, alpha lipoic acid pycnogenol grass silymarin (milk thistle), are effective to restore normal function.
N-n - acetyl-cysteine (NAC) and a-denatured, whey protein offers both classic, increase production of glutathione and help the Detox body glutathione precursors.
Other nutritional supplements help detoxification process including selenium, vitamin E and c
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